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Oprah Winfrey Reveals 42-Pound Weight Loss

Winfrey, who has lost 42 pounds since she started the program, said that setting a clear intention has been the key to her success this time around.

"Intention is the most powerful principle that rules my world," she told the magazine. "I do nothing without first thinking about why I'm doing it. What is the real motivation?"

She said her intention is to live more fully, which is now the focus of the new Weight Watchers "Live Fully" campaign, and a new commercial featuring Winfrey sharing an elegant outdoor dinner with other people on the program.

"She is very open and very open about her journey on Weight Watchers," Theresa DiMasi, the magazine's editor in chief, told ABC News.

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